Pilocarpine

Question: Which motorneurons are susceptible to status epilepticus in the pilocarpine-treated mouse?

Answer: tis like the subway put some liver in ur mouth In the middle of rush hour whore some year old mayonnaise meets yesterdays tuna It’s end of line.!!!!!!!!

Question: Can you help my mom with severe dry mouth and she takes pilocarpine and it seems like it isn't working as well? now. She tested negative for sjogren syndrome and blood work was negative. Anyone have any ideas?

Answer: continuous dry mouth is a sign of diabetes ,has it been tested ? also if that is not a problem some thing could be wrong with her salivary glands not producing enough saliva to keep mouth moist. In that case she will need to see an endocrinologist or any other doctor who deals with glands.

Question: What are the effects of acetylcholine, atropine, epinephrine, and pilocarpine on heart rate? in terms of neurotransmitters and reactive (receptor) sites.

Answer: acetylcholine is a neurotransmitter: works on ganglion and muscarinic receptors and nicotinic receptors which binds to these receptors causing increasing parasympathetic tone thus decreasing HR Atropine is a cholinergic antagonist which blocks the acetylcholine receptor causing increased sympathetic tone increasing the heart rate Epinephrine is an adrenergic agonist which binds to adrenergic receptors such as B1 and B2, or Alpha 1...these increase the HR Pilocarpine is a direct acting cholinergic agonist which decreases heart rate by directly acting on the receptor..this acts the same as acetylcholine.

Question: what type of antagonism is shown in phenylephrine vs pilocarpine?

Answer: nope.Pilocarpine, is a vegetal derivated alkaloid, that constricts the pupils, relaxing the radiated (dilating) fibers of the muscle in the iris,,,,, Phenilephrine, will dilate the pupil due to its "alpha action" that is similar to noradrenaline, causing the radiated muscle of the iris, to contract, and anlarge the pupil.+ The antagonist of pilocarpine, is ATROPINE drops 1% Phenilephrino WILL NOT antagonize the action of pilocarpine. since they work on different receptors (atropine antagonizes or blocks muscarinic receptors, meanwhile phenilephrine, dilates the pupils by stimulation of the alpha or adrenergic receptors...but cant be antagonized by pilocarpine and viceversa....only atropine or homatropine can do that).... as you see, they all use different receptors and ways....

Question: The drugs bethanechol and pilocarpine are? The drugs bethanechol and pilocarpine are: a) Nicotinic agonists b) Nicotinic antagonists c) Muscarinic agonists d) Muscarinic antagonists e) Acetylcholinesterase inhibitors

Answer: c) Muscarinic agonists

Question: What medications/drugs contain the chemicals Phentolamine , tolazoline, pilocarpine, physostigmine, or Acetazo What medications/drugs contain the chemicals Phentolamine , tolazoline, pilocarpine, physostigmine, or Acetazolamide?

Answer: those are all glaucoma medications

Question: Why pilocarpine is used in glaucoma?

Answer: Pilocarpine relieves the symptoms of glaucoma.

Question: What is the effect of atropine on pilocarpine in smooth muscle (ie. ileum)?

Answer: The overall action of atropine is to stimulate the sympathetic nervous system. In the gastrointestinal system, sympathetic stimulation inhibits peristalsis (the wave-like contractions of the intestines that move food along). The sympathetic nervous system also affects many other organs like the heart, where sympathetic stimulation increases heart rate, and force of contraction. The overall action of pilocarpine is to stimulate the parasympathetic nervous system. The parasympathetic nervous system opposes the effects of the sympathetic nervous system, so in the case of the gastrointestinal system, the effect would be to increase peristalsis and activity of the intestines.

Question: why is phenylephrine used for dilation over physostigmine or pilocarpine?

Answer: Both physostigmine and philocarpine are parasympathomimetics (mimic the parasympathetic nervous system). This can lead to bradycardias (slow heart rates) and excessive lacramentation (tearing of the eyes). Phenylephrine is an alpha agonist (alpha receptors of the sympathetic nervous system) and causes local vasoconstriction and mydriasis (dilation of the pupil). Phenylephrine is also a common nasal decongestant. There are better medications for mydriasis than any of the above.

Question: Which ion would you expect to have the greatest effect on a frog heart? Which of the following ions would you expect to have the greatest effect on a frog heart: atropine, epinephrine or pilocarpine? Why?

Answer: GOOGLE IT =)

Question: What plants native to New Jersey contain pilocarpine or other salivary stimulating drugs?

Answer: There are no pilocarpus which is a tropical shrub in the US according to the USDA except for Puerto Rico. input Pilocarpus http://www.plants.usda.gov/java/profile?…

Question: Pilocarpine is a parasympathomimetic drug, while atropine is a parasympatholytic drug. please explain that.?

Answer: Pilocarpine is used in glaucoma which decreases the intraocular pressure behind the eye. it is labeled a parasympathomimetic because it mimics the parasympathetic system Atropine is parasympatholytic which means it blocks the effects of the parasympethetic system (lytic means it inhibits the PNS)

Question: Glaucoma & Pilocarpine eye drops...? Why do people have to press on the nasolacrimal duct for like 30 sec when taking this medication??

Answer: Pressing the nasolacrimal duct helps to prevent the medication from draining into the tear ducts. The tear ducts drain into a vascularized area of the nose that is capable of absorbing the drug directly into the body. In other words, you minimize the body's absorption of the drug, but maximize the absorption into the eye. And an FYI, it's a good idea to do this with all ocular meds!

Question: What is the action of each of the following factors on heart rate? (1) pilocarpine (2) digitalis

Answer: Pilocarpine, a cholinergic drug, is a negative chronotrope (rate) and a negative inotrope (force of contraction) Digitalis, a cardiac glycoside, is a negative chronotrope and a positive inotrope.

Question: My husband has dry mouth from having radiation. What to do? His tongue sticks to the roof of his mouth while he is asleep. The doctor from the cancer center told him to use swabs. Swabs do not last long. He sips water during the night and he said that gets painful. He has all the benene things. He eats lemon drops and other sour candy and tart apples. He tried pickles. Pilocarpine can not be used for some reasons. Does anyone know what he can do?

Answer: Here's what a dietician at oncolink said about it. This was for a longer term problem, but it's fairly typical. Also, believe it or not, if nothing else helps, acupuncture has been very successful and is being incorporated by oncs at top places like Sloan Kettering. So if he's not needle-phobic, I'd google this or talk to his onc about it.

Question: Anyone know what works better than salagen? Anyone know what works better than salagen (pilocarpine) for radiation induced xerostomia?

Answer: study presented today at the annual meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO) reported that taking Salagen(R) Tablets (pilocarpine hydrochloride) during radiation therapy is better at reducing the symptoms of xerostomia (severe dry mouth) than when taking the drug after radiation therapy is completed. copied from this page www.docguide.com

Question: My husband has dry mouth from radiation. What can he use? The radiation damaged his saliva glands and taste buds. He has all the benene things. He eats lemon drops and other sour candy and tart apples.The swabs do not last long. He tried pickles. During the night his tongue sticks to the roof of his mouth.There are reasons for not using pilocarpine. Does anyone know about anything he can use?

Answer: jean ann - Your husband should consult his surgeon (? ENT physician) who certainly has had other treated patients with the same problem. For nighttime relief, try keeping a thermos with ice and water on his bedside night table so he can take sips of water. With radiation damage to his salivary glands and their ducts into the mouth, lemon and sour candy are not effective enough. Lime slices sometimes help a little.

Question: Can high powered dilating drops permanently effect vision? In February, I had surgery for intraocular lens replacement and latis(sp) degeneration to my right eye. During my surgery iris retractors were used bc I don't dilate well. I was given Pilocarpine(1%) to decrease my pupil size, but it didn't work for long. Also in my right eye, I still see ghost images and extra light;my rt eye's vision is not as sharp or fined tuned as before. When reading a certain font size(on paper and pc monitor) can be difficult to read.But I have been prescribed glasses(Im waiting for the glasses to come back). On this past Wednesday, my doctor wanted to determine if latis degeneration was present in my left eye, so my left eye was dilated with high-powered drops.So now it is Sunday, and I am still having a BIG problem reading smaller print on paper and pc monitors..Before being dilated, I had my left eye to depend on. I was told that it may take a few days for my eye to go back to normal, but this doesn't seem right. Can dilating drops permanently impair vision?

Answer: NO,dilating drops do not permanently affect one's vision. I am thinking that you probably already had problems with your vison but it only became apparent after the dilation as you double checked your vision given the concern you have about depending on your left eye. I would also suspect that if you have lattis degeneration in one eye you will have it in the other eye,if not now. . eventually as it would seem that when one eye develops a problem,the other eye eventually gets the same problem. . . .a type of sympathetic syndrome. Dilating drops affect only the pupil or iris as it actually is a muscle. Dilating drops relax the constricting and expanding abilities that the pupil/iris has. It wears off in time. Using Pilocarpine is definately a possibility to reverse the action of the dilating drops but is done only in extreme cases as it does have it's own side effects and they can be dangerous and can actually do more harm than good. I suspect that they used the Pilocarpine not only to make the pupil/iris shrink back down as it does help hold the intraocular lens in place. They also use "pressure" drops as a preventative to your having increased eye pressure in your eye after surgery. High powered eye drops such as Atropine DOES take a bit of time to wear off,it's the nature of the drop and the interaction with the body. . . .not to worry,it WILL wear off. Anytime a person has "degeneration" of any kind be it lattice degeneration or macular degeneration (dry/wet),there is going to be a change in vision and that change may or may not respond to treatment and hopefully your Dr told you this prior to the surgery you had. Because you had an intraocular lens put in tells me you probably had a cataract and yes it is possible that you have developed some "scar tissue" behind that implanted lens which is normal with this kind of surgery and when all of your healing is done in your right eye it is possible to have a few shots of laser to break open that scar tissue and help to improve the "ghost" images but with the lattice degeneration,this procedure may or may not help your vision in your right eye.

Question: why did the following chemicals effect heart rate? why did pilocarpine decrease heart rate? why did atropine increase heart rate? why did epinephrine increase heart rate? what division of the autonomic nervous system does the addition of epinephrine imitate? why did digitalis decrease in heart rate?

Answer: Digitalis is a positive inotrope so it increases cardiac contractility and thus cardiac output. It works by inhibiting Na-K ATPase thus increasing the Na intracellulary and thus the calcium supply (this ultimately increases contractility). Pilocarpine is a nonselective muscarinic receptor agonist. It causes bradycardia and hypotension - slows heart rate and lowers blood pressure. Atropine is a competitive antagonist of the muscarinic acetylcholine receptors. It is used to treat bradycardia or situations of cardiac arrest. It increases the heart rate.

Question: the following is a list of drugs that you will place on a beating frog heart. describe what you expect will? happen following the application of each drug. provide specific reasons to support your expectations. a. epinephrine b. atropine c. acetylcholine d. pilocarpine

Answer: a. Epinephrine - heart will speed up and contract more strongly (this is adrenaline) due to increased sympathetic stimulation. http://en.wikipedia.org/wiki/Autonomic_n… b. Atropine - the heart will speed up (this is a parasympatholytic - it inhibits the parasympathetic system by functioning as a competitve inhibitor of acetylcholine, which slows the heart) http://en.wikipedia.org/wiki/Atropine c. Acetylcholine - the heart will slow (this is the parasympathetic neurotransmitter) http://en.wikipedia.org/wiki/Autonomic_n… d. Pilocarpine - the heart will slow (this is a parasympathomimetic - it stimulates the the same acetylcholine receptors as the parasympathetic nervous system does) http://en.wikipedia.org/wiki/Pilocarpine