Streptokinase

Question: Why doesn't injection of streptokinase cause a streptococcal infecton? How do we know the streptokinase will digest fibrin only and not good tissues? if bacterial enzyme sreptokinase is used to digest fibrin in patients with atherosclerosis.

Answer: See the answer here: http://answers.yahoo.com/question/index;_ylt=Apn9xrp7U0pFt_IsjKku1qr9xQt.;_ylv=3?qid=20071004121651AAs2r7R

Question: The bacterial enzyme streptokinase is used to digest fibrin (blood clots) in patients with atherosclerosis.? The bacterial enzyme streptokinase is used to digest fibrin (blood clots) in patients with atherosclerosis. Why doesn’t injection of streptokinase cause a streptococcal infection? Why does the streptokinase only affect fibrin and not beneficial tissues around it?

Answer: Streptokinase actually indirectly breaks down blood clots via the activation of another enzyme known as plasminogen which ultimately cleaves into plasmin which is the "action taker" in breaking down clots. Since streptokinase is only an enzyme and not a weaken pathogen such as vaccines, streptococcus won't invade the host.

Question: how do we know that streptokinase will digest fibrin only and not good tisues?

Answer: It is an enzyme, all enzymes have specific targets due to protein makeup of the molecule. This enzyme is secreted to disolve clots which inhibit the spread of strep in the body.

Question: Which of the following enzymes is most the diagnostic after Myocardial infraction? a. LDH-4 b. CPK c. Ligase d. Streptokinase e. ALT/SGOT

Answer: The answer is b, but this is a poor question. Troponins are the gold standard for diagnosis in MI's. They are most specific to cardiac tissue and MI.

Question: Statistics question about probability and other stuff o_O for University? Please refer to the following data set (Please try to ignore the underscores; they're just for spacing purposes): ____________________Streptokinase group______Placebo group Died within 21 days____________54_______________63 Survived min. 21 days__________805______________819 Part a) Provide an appropriate graph [obviously you can't but I'd apprieciate a hint/graph type here] and measure of centrality for both the experimental group and the control group. [I don't know what that would be]. Be sure to explain what your measure of centrality is measuring for each of the groups. Part b) What is the conditonal probability for surviving a minimum 21 days after having the streptokinase infusion? [I got P=0.94, which is (805 / (805 + 54) ) Is that correct?] Part c) After the study, one person is randomly selected for an interview by the local media. What is the probability of being selected? [I got P = 0.00062, which is 1 / (805 + 819); not out of the total amount of people because some of them died. Is this answer correct?] Thank you a lot and please help if you can! Best answer points will be awarded to you!

Answer: You are right about parts b and c. I've got no idea about part (a). I suggest you to ask the part (a) in a separate question in YAHOO! answers.

Question: plz help me!? 20. The process of substances leaving a cell is _____. A. Endocytosis B. Pinocytosis C. Exocytosis 21. Offspring with a (tt) genotype would appear _____. A. Mix of tall and short B. All tall C. All short 22. _____ causes fatal brain deterioration in children to due the swelling and bursting of lysosomes in the brain cells. A. Hemophilia B. Phenylketonouria C. Sickle-cell anemia D. Cystic fibrosis E. Tay-Sachs disease 23. ______ is a tumor that remains in its original location. A. Benign B. Metastasize C. p53 D. Stayfast 24. Genes are sections of the DNA stand that code for certain proteins. DNA consists of two long, twisted chains made up of nucleotides; each nucleotide contains one base, one phosphate molecule, and the sugar molecule deoxyribose. A. True B. False 25. Humans can only live in a narrow pH window from 7.1 to _____. A. 7.7 B. 8.1 C. 8.3 D. 9.9 47. Pharmaceutical companies are already making human growth hormone, interferon, and streptokinase proteins. A. True B. False 48. After cytokinesis, the daughter cells return to interphase to begin the cell cycle anew. A. True B. False 49. When Mendel cross pollinated true breeding plants with contrasting characteristics for the same trait--the offspring exhibited traits the parent plants didn't exhibit. A. True B. False

Answer: 20 - a exocytosis 21 - c all short 22 - e Tay-Sachs disease 23 - a benign 24 - false -it contains a base, a sugar phospahe and a deoxyribose acid 25 - 7.7 48 - true in meiosis, fals ein mitosis 49 - a - true

Question: Why doesn't injection of streptokinase cause a streptococcal infecton? How do we know the streptokinase will digest fibrin only and not good tissues? if bacterial enzyme sreptokinase is used to digest fibrin in patients with atherosclerosis. subject:microbiology

Answer: Streptokinase is isolated from Streptococcus, but in a purified form and contains no whole, live Streptococcus bacteria, so it can't cause an infection. However, you can build an immunity to it, so subsequent administration after the initial dose could cause an allergic immune reaction, so you usually only get it once (after your first heart attack). Researchers are working on ways to find the portion of the the streptokinase molecule that results in plasminogen activation and produce only that portion so the peptide molecule can be used repeatedly if necessary and produced more inexpensively and in a purer form. Also, streptokinase is not a protease and so it won't digest other proteins or tissues directly. Streptokinase activates plasminogen (not proteolytically, but by binding to plasminogen allowing the complex to proteolytically activate other plasminogen molecules) and plasmin is made. Plasmin is the protease that dissolves fibrin. Since streptokinase is inexpensive compared to some of the alternatives (tPA, tissue-type plasminogen activator) and the efficacy is similar, streptokinase it is still widely used.

Question: Why doesn't an injection of streptokinase cause a streptococcal infection? The bacterial enzyme streptokinase is used to digest fibrin (blood clots) in patients with athersclerosis. Why doesn't injection of streptokinase cause a streptococcal infection? How do we know the streptokinase will digest fibrin only and not good tissue?

Answer: I'm pretty sure those are two different bacteria. A streptococcal infection is caused by streptococcus.

Question: How does streptokinase improve the prognosis for patients?

Answer: It stimulates the body to produce plasmin which is a substance that breaks down the blood clot which is blocking the coronary artery. This restore blood flow to the heart more quickly and reduces the damage to the myocardium (heart muscle) caused by ischamea (lack of Oxygen).

Question: should streptokinase injection be given to high BP patient? please someone with medical knowledge regarding streptokinase injection tell me. my mother ecg was taken and the report suggested she would get an heart attack so we rushed her to the hospital she was absolutely fine we told her some medical test has to be done. when we reached this hospital the doctor told us they would give an injection which would thinner the blood and would cost 15 thousand rupees after few minute they told us there is another injection streptokinase cost rupees 30 thousand and that is much better. we said u do anything but my mother should be ok later the doctor asked did my mother have any sickness my sister told the doctor she has high BP and she takes ATEN tablets and other medicine as prescribed. the doctor still proceeded with the same injection streptokinase. immediately my mother BP started to drop and drop and she expired i asked the doctor i brought my mother for precaution people have heart attack and still survive my mother did not have any attack we took the ecg bcos in the night her right hand was paining and our family doctor suggested for ecg. how this happened doctor. he told us she got an heart attack. after speaking to people and net i found out my mummy got an heart attack not Naturally. but bcos the injection is not meant for high BP patient it has side effect of low BP that means less blood or no blood to heart was the vein ruptured pls i will be greatful if someone answer me this question or pls pls email me at paradisodb@yahoo.com

Answer: streptokinase injection is given to patients to prevent or break up blood clots. It is typically given to someone with high blood pressure since a lot of high blood pressure patients have heart problems. I'm so sorry for the loss of your mom. Best of luck in your grieving/recovery.

Question: What enzymes are used in medicine? I need to know three different enzymes that can be used in medicine. I need to know the enzyme used, and I need to be able to give the effect of using that enzyme. I can't use the following enzymes as they are examples, Lipase Streptokinase And an enzyme that cures Leukaemia Thanks

Answer: I need to know three different enzymes that can be used in medicine. Urokinase Lactase Protease And an enzyme that cures Leukaemia Asparaginase

Question: Should streptokinase injection be given to high BP patient? My aunt was admitted to Life Line Hospital (Mumbai), doctors took her ECG at 12.30 afternoon it reported mild attack, she was put in ICU, she was talking with us in afternoon things looked that she will be fine by some medical treatment. Later at 3.00 pm doctors told that she need to be given an injection which either cost 5000, 15,000 or 30000. I suggested for 5000 rs injection after sometime her blood pressure reported very low and later she died doctors told me she got a massive heart attack. Now my questions are 1. Does that injection caused her attack because of low blood pressure. 2. Would have she survived if 30000 rs injection had been given. 3. She was a diabetic doctor said she had a blood clot in heart but diabetics people do not feel pain as their nerves become senseless so big heart attacks seems minor to them.

Answer: it is contraindicated in patients with persistent systolic BP>200mmHg, the other answers are 1) no 2) no 3) the doctor is right.

Question: What drug is taken in small doses on a continuing basis to reduce platelet adhesion? a. acetylsalicylic (ASA) b. streptokinase c. acetaminophen d. idiopathic

Answer: aspirin

Question: Why can't there be a built in release of streptokinase in the heart for thrombolysis? Like, if there were a pouch in the heart. When it detects troponin release during a heart attack, it just releases streptokinase in the heart and begins to dissolve the clot.

Answer: For one thing, there's not the technology to do it. For another, there are some other reasons for elevated troponins. You wouldn't want the "device" to fire for no reason. Lastly, how would it be placed/replaced? Nice idea, not practical.